Moxatag and Truvada Info

Moxatag (775 mg Amoxicillin XR)
Approved 1/23/08 for adults and children>12 y/o
Used for tonsillitis or pharyngitis secondary to streptococcus pyogenes.

**Consists of 3 active amoxicillin components. 1 component is an immediate release component that releases in the stomach. The other 2 layers are delayed release and they release their effectiveness based on pH in the GI tract.**

Normal dose = 775 mg once daily x 10 days
Mech. of Action = Inhibits bacterial cell wall synthesis
Take tablet within 1 hr of finishing meal
Do not crush or chew
Clavulanic Acid: Part of the combo in Augmentin XR
Member of the beta lactam family of Abx with little or no intrinsic antibacterial activity of its own.
Used to enhance activity of Abx by blocking bacterial lactamasas
--blocks the active sites of these enzymes
--particularly active against the clinically important plasmid-mediated beta lactamases frequently responsible for transferred drug resistance to pen and ceph.
**I'm still not sure why you would use the Moxatag over the Augmentin since it doesn't have the clavulanic acid except that is is once daily dosing. How do doctors know if they need the clavulanic acid???

Truvada (emtricitabine 200 mg + tenofovir 300 mg)
Emtricitabine = nucleoside analog
Tenofovir = nucleotide analog

Anti HIV drug used in combo with other meds to treat HIV-1 infection in adults.
Should not be used in combo with adefovir, tenofovir, lamivudine.
Does not cure HIV or reduce the chances of passing the virus on

Both ingredients ar part of the nucleoside reverse transcriptase inhibitor family
Usual dose = 1 tab daily with or without meals
Dosing interval must be increased in patients with renal impairment (CrCl<50). Not recommended if CrCl<30.

Reverse transcriptase is a viral DNA polymerase enzyme that retroviruses need to reproduce. It transcribs single stranded RNA into single stranded DNA. It helps in the formation of the double helix DNA.

Pricing: 30 tabs = $946.63 (wow!)

** There is a fabulous video on how Truvada works at www.truvada.com/pat100_about_truvada.aspx. Enjoy! **